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Article

Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level

1 Jan 2017

Abstract excerpt

While several studies link the cell-surface marker CD44 to cancer progression, conflicting results show both positive and negative correlations with increased CD44 levels. Here, we demonstrate that the survival outcomes of genetically induced glioma-bearing mice and of high-grade human glioma patients are biphasically correlated with CD44 level, with the poorest outcomes occurring at intermediate levels....

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Identifiers

PMID: 28052252
DOI: 10.1016/j.celrep.2016.12.024

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