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Article

Single Cell Mathematical Model Successfully Replicates Key Features of GBM: Go-Or-Grow Is Not Necessary.

PloS one - 1 Jan 2017

Scribner Elizabeth, Fathallah-Shaykh Hassan M

Abstract excerpt

Glioblastoma (GBM) is a malignant brain tumor that continues to be associated with neurological morbidity and poor survival times. Brain invasion is a fundamental property of malignant glioma cells. The Go-or-Grow (GoG) phenotype proposes that cancer cell motility and proliferation are mutually exclusive. Here, we construct and apply a single glioma cell mathematical model that includes motility and angiogenesis...

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Identifiers

PMID: 28046101
DOI: 10.1371/journal.pone.0169434
PMCID: PMC5207515

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