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Article

Association of TLR3 L412F Polymorphism with Cytomegalovirus Infection in Children.

PloS one - 1 Jan 2017

Studzińska Mirosława, Jabłońska Agnieszka, Wiśniewska-Ligier Małgorzata, Nowakowska Dorota, Gaj Zuzanna, Leśnikowski Zbigniew J, Woźniakowska-Gęsicka Teresa, Wilczyński Jan, Paradowska Edyta

Abstract excerpt

Intracellular Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (dsRNA) and activates antiviral immune responses through the production of type I interferons (IFNs) and inflammatory cytokines. This receptor binds to dsRNA molecules produced during human cytomegalovirus (HCMV) replication. TLR7 senses viral single-stranded RNA (ssRNA) in endosomes, and it can interact with endogenous RNAs. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28046022
DOI: 10.1371/journal.pone.0169420
PMCID: PMC5207783

Genes

TLR3
TLR7

Variants

rs3775291
rs3775290
rs3775291
rs179008
rs5741880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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