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Article

Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin.

Scientific reports - 3 Jan 2017

Khan Shafaat Y, Awad Ezzat M, Oszwald Andre, Mayr Manuel, Yin Xiaoke, Waltenberger Birgit, Stuppner Hermann, Lipovac Markus, Uhrin Pavel, Breuss Johannes M

Abstract excerpt

Cellular senescence is characterized by a permanent cell-cycle arrest and a pro-inflammatory secretory phenotype, and can be induced by a variety of stimuli, including ionizing radiation, oxidative stress, and inflammation. In endothelial cells, this phenomenon might contribute to vascular disease. Plasma levels of the inflammatory cytokine tumor necrosis factor alpha (TNFα) are increased in age-related and...

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Identifiers

PMID: 28045034
DOI: 10.1038/srep39501
PMCID: PMC5206708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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