Article
Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue.
Molecular cancer research : MCR - 1 Apr 2017
Snowden Eileen, Porter Warren, Hahn Friedrich, Ferguson Mitchell, Tong Frances, Parker Joel S, Middlebrook Aaron, Ghanekar Smita, Dillmore W Shannon, Blaesius Rainer
Abstract excerpt
Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity, whereas single-cell imaging methods limit the number of cells which can be assessed or are very resource intensive. The current study presents methods based on flow cytometric analysis and cell sorting using...
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