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Article

Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive.

Genome biology - 30 Dec 2016

Nellore Abhinav, Jaffe Andrew E, Fortin Jean-Philippe, Alquicira-Hernández José, Collado-Torres Leonardo, Wang Siruo, Phillips Robert A, Karbhari Nishika, Hansen Kasper D, Langmead Ben, Leek Jeffrey T

Abstract excerpt

BACKGROUND: Gene annotations, such as those in GENCODE, are derived primarily from alignments of spliced cDNA sequences and protein sequences. The impact of RNA-seq data on annotation has been confined to major projects like ENCODE and Illumina Body Map 2.0. RESULTS: We aligned 21,504 Illumina-sequenced human RNA-seq samples from the Sequence Read Archive (SRA) to the human genome and compared detected exon-exon...

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Identifiers

PMID: 28038678
DOI: 10.1186/s13059-016-1118-6
PMCID: PMC5203714

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ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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