Article
Identification of somatic VHL gene mutations in sporadic head and neck paragangliomas in association with activation of the HIF-1α/miR-210 signaling pathway.
The Journal of clinical endocrinology and metabolism - 1 Oct 2013
Merlo Anna, de Quirós Sandra Bernaldo, de Santa-María Inés Sáenz, Pitiot Ana S, Balbín Milagros, Astudillo Aurora, Scola Bartolomé, Arístegui Miguel, Quer Miquel, Suarez Carlos, Chiara María-Dolores
Abstract excerpt
CONTEXT: Head and neck paragangliomas (HNPGLs) arise from parasympathetic paraganglias and 35% to 45% are hereditary caused by mutations in succinate dehydrogenase (SDH) genes. The connection between SDH and tumor development is unclear. The most accepted hypothesis proposes a central role for the pseudohypoxic (pHx) pathway activated by hypoxia-inducible factor (HIF). Paradoxically, we showed that activation of...
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