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Article

The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.

Biochemical and biophysical research communications - 29 Jan 2017

Nakata Daisuke, Nakao Shoichi, Nakayama Kazuhide, Araki Shinsuke, Nakayama Yusuke, Aparicio Samuel, Hara Takahito, Nakanishi Atsushi

Abstract excerpt

Mounting evidence suggests that constitutively active androgen receptor (AR) splice variants, typified by AR-V7, are associated with poor prognosis and resistance to androgen deprivation therapy in prostate cancer patients. However, mechanisms governing the generation of AR splice variants are not fully understood. In this study, we aimed to investigate the dynamics of AR splice variant generation using the JDCaP...

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Source

Identifiers

PMID: 28025139
DOI: 10.1016/j.bbrc.2016.12.153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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