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JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

15 Feb 2021

Abstract excerpt

Abstract Endocrine resistance (EnR) in advanced prostate cancer is fatal. EnR can be mediated by androgen receptor (AR) splice variants, with AR splice variant 7 (AR-V7) arguably the most clinically important variant. In this study, we determined proteins key to generating AR-V7, validated our findings using clinical samples, and studied splicing regulatory mechanisms in prostate cancer models. Triangulation...

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PMID: 33822745
DOI: 10.1158/0008-5472.can-20-1807

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