MicroRNAs and their variants in an RNA world: implications for complex interactions and diverse roles in an RNA regulatory network.

Abstract excerpt

Multiple microRNA (miRNA) variant (isomiR) sequences have been identified at miRNA loci, suggesting that the miRNA sequence is not a single sequence but a series of isomiR sequences with sequence and expression heterogeneities. These isomiRs may be considered a large gene family with diverse expression patterns or a mini-gene cluster with high levels of sequence similarity. Although the isomiRs are diverse and...

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