Article
Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma.
Human molecular genetics - 15 Jan 2017
Ni Ying, Seballos Spencer, Fletcher Benjamin, Romigh Todd, Yehia Lamis, Mester Jessica, Senter Leigha, Niazi Farshad, Saji Motoyasu, Ringel Matthew D, LaFramboise Thomas, Eng Charis
Abstract excerpt
Cowden syndrome (CS) is an autosomal dominant disorder that predisposes to breast, thyroid, and other epithelial cancers. Differentiated thyroid carcinoma (DTC), as one of the major component cancers of CS, is the fastest rising incident cancer in the USA, and the most familial of all solid tumours. To identify additional candidate genes of CS and potentially DTC, we analysed a multi-generation CS-like family...
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