Article
Validation of VX2 as a Hepatocellular Carcinoma Model: Comparison of the Molecular Reaction of VX2 and HepG2 Tumor Cells to Sorafenib In Vitro.
Anticancer research - 1 Jan 2017
Nass Norbert, Streit Sebastian, Wybranski Christian, Jürgens Julian, Brauner Jan, Schulz Nadine, Powerski Maciej, Ricke Jens, Kalinski Thomas, Dudeck Oliver, Seidensticker Max
Abstract excerpt
As there is currently no superior hepatocellular carcinoma (HCC) model with percutaneous vascular access for transarterial treatments available, the VX2 rabbit model is frequently used for in vivo investigations on liver carcinoma. However, the VX2 cell line was derived from a virus-induced skin papilloma that can form carcinosarcoma in liver of rabbits and the transferability of obtained results to HCC treatment...
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