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Article

Disease-Concordant Twins Empower Genetic Association Studies.

Annals of human genetics - 1 Jan 2017

Tan Qihua, Li Weilong, Vandin Fabio

Abstract excerpt

Genome-wide association studies with moderate sample sizes are underpowered, especially when testing SNP alleles with low allele counts, a situation that may lead to high frequency of false-positive results and lack of replication in independent studies. Related individuals, such as twin pairs concordant for a disease, should confer increased power in genetic association analysis because of their genetic...

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PMID: 28009044
DOI: 10.1111/ahg.12181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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