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Article

Detection of D151G/N mutations in the neuraminidase gene of influenza A (H3N2) viruses by real-time RT-PCR allelic discrimination assay.

Journal of medical virology - 1 Jul 2017

Zadeh Vahid Rajabali, Jagadesh Anitha, Krishnan Anjana, Arunkumar Govindakarnavar

Abstract excerpt

Single nucleotide polymorphisms (SNPs) at D151 position of neuraminidase (NA) gene of influenza A (H3N2) virus has been associated with drug resistance and increased binding affinity. NA-D151G/N-substitutions of influenza A (H3N2) viruses are frequently induced and selected by culturing in Madin-Darby canine kidney (MDCK) cell lines. It is important to consider and exclude D151G/N mutants after isolation of...

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PMID: 28004398
DOI: 10.1002/jmv.24757

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