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Developmental Basis of Nanophthalmos: <i>MFRP</i> Is Required for both Prenatal Ocular Growth and Postnatal Emmetropization

1 Jan 2008

Abstract excerpt

BACKGROUND: Nanophthalmos is a genetic disorder characterized by very small, hyperopic eyes that are without gross structural defects. Recessive nanophthalmos is caused by severe mutations in the MFRP gene, which encodes a Frizzled-related transmembrane protein that is selectively expressed in the retinal pigment epithelium (RPE) and ciliary body. RESULTS: For two MFRP -/- adults, we have obtained records of...

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PMID: 18363166
DOI: 10.1080/13816810701651241

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Developmental Basis of Nanophthalmos: <i>MFRP</i> Is Required for both Prenatal Ocular Growth and Postnatal EmmetropizationPMID 18363166Read ↗

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