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Gene Therapy Restores Mfrp and Corrects Axial Eye Length

17 Nov 2017

Abstract excerpt

Abstract Hyperopia (farsightedness) is a common and significant cause of visual impairment, and extreme hyperopia (nanophthalmos) is a consequence of loss-of-function MFRP mutations. MFRP deficiency causes abnormal eye growth along the visual axis and significant visual comorbidities, such as angle closure glaucoma, cystic macular edema, and exudative retinal detachment. The Mfrp rd6 /Mfrp rd6 mouse is used as a...

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PMID: 29170418
DOI: 10.1038/s41598-017-16275-8

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