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Aging impairs double-strand break repair by homologous recombination in Drosophila germ cells

21 Dec 2016

Abstract excerpt

Aging is characterized by genome instability, which contributes to cancer formation and cell lethality leading to organismal decline. The high levels of DNA double-strand breaks (DSBs) observed in old cells and premature aging syndromes are likely a primary source of genome instability, but the underlying cause of their formation is still unclear. DSBs might result from higher levels of damage or repair defects...

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PMID: 28000382
DOI: 10.1111/acel.12556

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