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Article

Downregulation of Homer1b/c in SOD1 G93A Models of ALS: A Novel Mechanism of Neuroprotective Effect of Lithium and Valproic Acid.

International journal of molecular sciences - 17 Dec 2016

Jiang Hai-Zhi, Wang Shu-Yu, Yin Xiang, Jiang Hong-Quan, Wang Xu-Dong, Wang Jing, Wang Tian-Hang, Qi Yan, Yang Yue-Qing, Wang Ying, Zhang Chun-Ting, Feng Hong-Lin

Abstract excerpt

BACKGROUND: Mutations in the Cu/Zn superoxide dismutase (SOD1) gene have been linked to amyotrophic lateral sclerosis (ALS). However, the molecular mechanisms have not been elucidated yet. Homer family protein Homer1b/c is expressed widely in the central nervous system and plays important roles in neurological diseases. In this study, we explored whether Homer1b/c was involved in SOD1 mutation-linked ALS....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27999308
DOI: 10.3390/ijms17122129
PMCID: PMC5187929

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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