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Article

HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation.

Nucleic acids research - 1 Jan 2010

Mercenne Gaëlle, Bernacchi Serena, Richer Delphine, Bec Guillaume, Henriet Simon, Paillart Jean-Christophe, Marquet Roland

Abstract excerpt

The HIV-1 viral infectivity factor (Vif) allows productive infection of non-permissive cells (including most natural HIV-1 targets) by counteracting the cellular cytosine deaminases APOBEC-3G (hA3G) and hA3F. The Vif-induced degradation of these restriction factors by the proteasome has been exte...

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Source

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Identifiers

PMID: 19910370
DOI: 10.1093/nar/gkp1009
PMCID: PMC2810999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19910370-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation.PMID 19910370Read ↗

Translational regulation of APOBEC3G mRNA by Vif requires its 5'UTR and contributes to restoring HIV-1 infectivity.Semantic proximity Read ↗

HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both Its Translation and Intracellular StabilitySemantic proximity Read ↗

Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3G.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Vif Functionally Interacts with Diverse APOBEC3 Cytidine Deaminases and Moves with Them between Cytoplasmic Sites of mRNA MetabolismSemantic proximity Read ↗

HIV-1 Vif promotes the formation of high molecular mass APOBEC3G complexes.Semantic proximity Read ↗

Tumultuous Relationship between the Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) and the Human APOBEC-3G and APOBEC-3F Restriction FactorsSemantic proximity Read ↗

Functional domains of APOBEC3G required for antiviral activity.Semantic proximity Read ↗

Structural perspectives on HIV‐1 Vif and APOBEC3 restriction factor interactionsSemantic proximity Read ↗

Derepression of microRNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and its family members.Semantic proximity Read ↗

APOBEC3G Impairs the Multimerization of the HIV-1 Vif Protein in Living CellsSemantic proximity Read ↗

Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Status of APOBEC3G/F in cells and progeny virions modulated by Vif determines HIV-1 infectivity.Semantic proximity Read ↗

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