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Article

HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation.

Nucleic acids research - 1 Jan 2010

Mercenne Gaëlle, Bernacchi Serena, Richer Delphine, Bec Guillaume, Henriet Simon, Paillart Jean-Christophe, Marquet Roland

Abstract excerpt

The HIV-1 viral infectivity factor (Vif) allows productive infection of non-permissive cells (including most natural HIV-1 targets) by counteracting the cellular cytosine deaminases APOBEC-3G (hA3G) and hA3F. The Vif-induced degradation of these restriction factors by the proteasome has been extensively studied, but little is known about the translational repression of hA3G and hA3F by Vif, which has also been...

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Identifiers

PMID: 19910370
DOI: 10.1093/nar/gkp1009
PMCID: PMC2810999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation.PMID 19910370Read ↗

Translational regulation of APOBEC3G mRNA by Vif requires its 5'UTR and contributes to restoring HIV-1 infectivity.Semantic proximity Read ↗

HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both Its Translation and Intracellular StabilitySemantic proximity Read ↗

Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3G.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Vif Functionally Interacts with Diverse APOBEC3 Cytidine Deaminases and Moves with Them between Cytoplasmic Sites of mRNA MetabolismSemantic proximity Read ↗

HIV-1 Vif promotes the formation of high molecular mass APOBEC3G complexes.Semantic proximity Read ↗

Tumultuous Relationship between the Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) and the Human APOBEC-3G and APOBEC-3F Restriction FactorsSemantic proximity Read ↗

Functional domains of APOBEC3G required for antiviral activity.Semantic proximity Read ↗

Structural perspectives on HIV‐1 Vif and APOBEC3 restriction factor interactionsSemantic proximity Read ↗

Derepression of microRNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and its family members.Semantic proximity Read ↗

APOBEC3G Impairs the Multimerization of the HIV-1 Vif Protein in Living CellsSemantic proximity Read ↗

Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Status of APOBEC3G/F in cells and progeny virions modulated by Vif determines HIV-1 infectivity.Semantic proximity Read ↗

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