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Article

Possible Implication of GSTP1 and NQO1 Polymorphisms on Natalizumab Response in Multiple Sclerosis.

Annals of clinical and laboratory science - 1 Dec 2016

Alexoudi Athanasia, Zachaki Sophia, Stavropoulou Chrysa, Gavrili Stavroula, Spiliopoulou Chara, Papadodima Stavroula, Karageorgiou Clementine E, Sambani Constantina

Abstract excerpt

Oxidative stress plays a pivotal role in the pathogenesis of multiple sclerosis (MS). Inactivating polymorphism of genes encoding detoxification enzymes, such as NQO1 and GSTP1 could influence susceptibility to MS. The monoclonal antibody natalizumab is an effective treatment in MS. Natalizumab's efficacy in MS patients with regard to NQO1 and GSTP1 genetic polymorphisms is investigated. 130 patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NAD(P)H Dehydrogenase (Quinone)

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 27993870

Genes

GSTP1
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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