Article
The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease.
Free radical biology & medicine - 1 Aug 2011
Stavropoulou Chrysa, Zachaki Sophia, Alexoudi Athanasia, Chatzi Ioanna, Georgakakos Vasileios N, Terzoudi Georgia I, Pantelias Gabriel E, Karageorgiou Clementine E, Sambani Constantina
Abstract excerpt
Oxidative stress plays a pivotal role in the pathogenesis of multiple sclerosis (MS). Inactivating polymorphisms of genes encoding detoxification enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1), could influence susceptibility to MS. To test this hypothesis we performed a case-control study in which we compared the distribution of NQO1 genotypes between 231 MS patients and 380 controls, using both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.