Performance of the G4 Xpert® MTB/RIF assay for the detection of Mycobacterium tuberculosis and rifampin resistance: a retrospective case-control study of analytical and clinical samples from high- and low-tuberculosis prevalence settings.

doi:10.1186/s12879-016-2039-4

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Article

Performance of the G4 Xpert® MTB/RIF assay for the detection of Mycobacterium tuberculosis and rifampin resistance: a retrospective case-control study of analytical and clinical samples from high- and low-tuberculosis prevalence settings.

BMC infectious diseases - 20 Dec 2016

Dharan Nila J, Blakemore Robert, Sloutsky Alex, Kaur Devinder, Alexander Richard C, Ghajar Minoo, Musser Kimberlee A, Escuyer Vincent E, Rowlinson Marie-Claire, Crowe Susanne, Laniado-Laborin Rafael, Valli Eloise, Nabeta Pamela, Johnson Pamela, Alland David

Abstract excerpt

BACKGROUND: The Xpert® MTB/RIF (Xpert) assay is a rapid PCR-based assay for the detection of Mycobacterium tuberculosis complex DNA (MTBc) and mutations associated with rifampin resistance (RIF). An updated version introduced in 2011, the G4 Xpert, included modifications to probe B and updated analytic software. METHODS: An analytical study was performed to assess Xpert detection of mutations associated with...

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Identifiers

PMID: 27993132
DOI: 10.1186/s12879-016-2039-4
PMCID: PMC5168809

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