The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing.

doi:10.1128/mBio.00812-17

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The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing.

mBio - 29 Aug 2017

Chakravorty Soumitesh, Simmons Ann Marie, Rowneki Mazhgan, Parmar Heta, Cao Yuan, Ryan Jamie, Banada Padmapriya P, Deshpande Srinidhi, Shenai Shubhada, Gall Alexander, Glass Jennifer, Krieswirth Barry, Schumacher Samuel G, Nabeta Pamela, Tukvadze Nestani, Rodrigues Camilla, Skrahina Alena, Tagliani Elisa, Cirillo Daniela M, Davidow Amy, Denkinger Claudia M, Persing David, Kwiatkowski Robert, Jones Martin, Alland David

Abstract excerpt

The Xpert MTB/RIF assay (Xpert) is a rapid test for tuberculosis (TB) and rifampin resistance (RIF-R) suitable for point-of-care testing. However, it has decreased sensitivity in smear-negative sputum, and false identification of RIF-R occasionally occurs. We developed the Xpert MTB/RIF Ultra assay (Ultra) to improve performance. Ultra and Xpert limits of detection (LOD), dynamic ranges, and RIF-R rpoB mutation...

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Identifiers

PMID: 28851844
DOI: 10.1128/mBio.00812-17
PMCID: PMC5574709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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