A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study.

doi:10.1002/ejhf.706

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Article

A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study.

European journal of heart failure - 1 Mar 2017

Angermann Christiane E, Kaspar Mathias, Marx Almuth, Kittel-Schneider Sarah, Menhofer Dominik, Störk Stefan, Ertl Georg, Domschke Katharina, Deckert Jürgen, Reif Andreas

Abstract excerpt

AIMS: Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms. We investigated all-cause death and re-hospitalization (composite primary endpoint, CPEP) and...

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PMID: 27990720
DOI: 10.1002/ejhf.706

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NPSR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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