Article
Rhabdoid and Undifferentiated Phenotype in Renal Cell Carcinoma: Analysis of 32 Cases Indicating a Distinctive Common Pathway of Dedifferentiation Frequently Associated With SWI/SNF Complex Deficiency.
The American journal of surgical pathology - 1 Feb 2017
Agaimy Abbas, Cheng Liang, Egevad Lars, Feyerabend Bernd, Hes Ondřej, Keck Bastian, Pizzolitto Stefano, Sioletic Stefano, Wullich Bernd, Hartmann Arndt
Abstract excerpt
Undifferentiated (anaplastic) and rhabdoid cell features are increasingly recognized as adverse prognostic findings in renal cell carcinoma (RCC), but their molecular pathogenesis has not been studied sufficiently. Recent studies identified alterations in the Switch Sucrose nonfermentable (SWI/SNF) chromatin remodeling complex as molecular mechanisms underlying dedifferentiation and rhabdoid features in...
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