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Article

SWI/SNF protein expression status in fumarate hydratase-deficient renal cell carcinoma: immunohistochemical analysis of 32 tumors from 28 patients.

Human pathology - 1 Jul 2018

Agaimy Abbas, Amin Mahul B, Gill Anthony J, Popp Bernt, Reis André, Berney Daniel M, Magi-Galluzzi Cristina, Sibony Mathilde, Smith Steven C, Suster Saul, Trpkov Kiril, Hes Ondřej, Hartmann Arndt

Abstract excerpt

Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare, aggressive RCC type, originally described in the setting of hereditary leiomyomatosis and RCC syndrome, which is defined by germline FH gene inactivation. Inactivation of components of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex is involved in renal medullary carcinoma (SMARCB1/INI1 loss), clear cell RCC (PBRM1...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29689242
DOI: 10.1016/j.humpath.2018.04.004

Genes

SMARCB1
PBRM1
SMARCC1
SMARCA2
SMARCA4
SMARCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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