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Article

PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis.

Journal of cell science - 1 Feb 2017

Ihara Shinji, Nakayama Sohei, Murakami Yoshiko, Suzuki Emiko, Asakawa Masayo, Kinoshita Taroh, Sawa Hitoshi

Abstract excerpt

Quality control of proteins in the endoplasmic reticulum (ER) is essential for ensuring the integrity of secretory proteins before their release into the extracellular space. Secretory proteins that fail to pass quality control form aggregates. Here we show the PIGN-1/PIGN is required for quality control in Caenorhabditis elegans and in mammalian cells. In C. elegans pign-1 mutants, several proteins fail to be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27980068
DOI: 10.1242/jcs.196717

Genes

PIGN
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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