Article
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase.
Nucleic acids research - 1 Nov 2010
Pecsi Ildiko, Leveles Ibolya, Harmat Veronika, Vertessy Beata G, Toth Judit
Abstract excerpt
Aromatic interactions are well-known players in molecular recognition but their catalytic role in biological systems is less documented. Here, we report that a conserved aromatic stacking interaction between dUTPase and its nucleotide substrate largely contributes to the stabilization of the asso...
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