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Article

Detecting coevolving amino acid sites using Bayesian mutational mapping.

Bioinformatics (Oxford, England) - 1 Jun 2005

Dimmic Matthew W, Hubisz Melissa J, Bustamante Carlos D, Nielsen Rasmus

Abstract excerpt

MOTIVATION: The evolution of protein sequences is constrained by complex interactions between amino acid residues. Because harmful substitutions may be compensated for by other substitutions at neighboring sites, residues can coevolve. We describe a Bayesian phylogenetic approach to the detection of coevolving residues in protein families. This method, Bayesian mutational mapping (BMM), assigns mutations to the...

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PMID: 15961449
DOI: 10.1093/bioinformatics/bti1032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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