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Staphylococcus aureus, phagocyte NADPH oxidase and chronic granulomatous disease

31 Oct 2016

Abstract excerpt

Dysfunction of phagocytes is a relevant risk factor for staphylococcal infection. The most common hereditary phagocyte dysfunction is chronic granulomatous disease (CGD), characterized by impaired generation of reactive oxygen species (ROS) due to loss of function mutations within the phagocyte NADPH oxidase NOX2. Phagocytes ROS generation is fundamental to eliminate pathogens and to regulate the inflammatory...

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PMID: 27965320
DOI: 10.1093/femsre/fuw042

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