Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis.

doi:10.1371/journal.pone.0168159

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Article

Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis.

PloS one - 1 Jan 2016

Tian Cong, Harris Belinda S, Johnson Kenneth R

Abstract excerpt

Otitis media (OM), inflammation of the middle ear, is a common cause of hearing loss in children and in patients with many different syndromic diseases. Studies of the human population and mouse models have revealed that OM is a multifactorial disease with many environmental and genetic contributing factors. Here, we report on otitis media-related hearing loss in asj (ages with stiffened joints) mutant mice,...

Topics

Animals
Ear, Middle
Genotype
Hearing Loss, Conductive
Inflammation
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mice, Transgenic
Microscopy, Electron, Scanning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Myringosclerosis

Otitis Media

Phosphoric Diester Hydrolases

Pyrophosphatases

Rickets, Hypophosphatemic

Source

Open in PubMed Open full text

Identifiers

PMID: 27959908
DOI: 10.1371/journal.pone.0168159
PMCID: PMC5154548

Genes

ABR
ENPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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