Article
Eya4-deficient mice are a model for heritable otitis media.
The Journal of clinical investigation - 1 Feb 2008
Depreux Frederic F S, Darrow Keith, Conner David A, Eavey Roland D, Liberman M Charles, Seidman Christine E, Seidman J G
Abstract excerpt
Otitis media is an extremely common pediatric inflammation of the middle ear that often causes pain and diminishes hearing. Vulnerability to otitis media is due to eustachian tube dysfunction as well as other poorly understood factors, including genetic susceptibility. As EYA4 mutations cause sensorineural hearing loss in humans, we produced and characterized Eya4-deficient (Eya4(-/-)) mice, which had severe...
Topics
- Animals
- Disease Models, Animal
- Ear, Middle
- Eustachian Tube
- Genetic Predisposition to Disease
- Hearing Loss, Sensorineural
- Mice
- Mice, Mutant Strains
- Mutation
- Otitis Media with Effusion
- Trans-Activators