Article
Mcph1-deficient mice reveal a role for MCPH1 in otitis media.
PloS one - 1 Jan 2013
Chen Jing, Ingham Neil, Clare Simon, Raisen Claire, Vancollie Valerie E, Ismail Ozama, McIntyre Rebecca E, Tsang Stephen H, Mahajan Vinit B, Dougan Gordon, Adams David J, White Jacqueline K, Steel Karen P
Abstract excerpt
Otitis media is a common reason for hearing loss, especially in children. Otitis media is a multifactorial disease and environmental factors, anatomic dysmorphology and genetic predisposition can all contribute to its pathogenesis. However, the reasons for the variable susceptibility to otitis media are elusive. MCPH1 mutations cause primary microcephaly in humans. So far, no hearing impairment has been reported...
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