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Article

Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants.

Nature communications - 13 Dec 2016

Yilmazer Yasemin B, Koganezawa Masayuki, Sato Kosei, Xu Jinhua, Yamamoto Daisuke

Abstract excerpt

Drosophila platonic (plt) males court females, but fail to copulate. Here we show that plt is an allele of scribbler (sbb), a BMP signalling component. sbb knockdown in larvae leads to the loss of approximately eight serotonergic neurons, which express the sex-determinant protein Doublesex (Dsx). Genetic deprivation of serotonin (5-HT) from dsx-expressing neurons results in copulation defects. Thus, sbb+ is...

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Identifiers

PMID: 27958269
DOI: 10.1038/ncomms13792
PMCID: PMC5159827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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