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Article

A double-negative gene regulatory circuit underlies the virgin behavioral state.

Cell reports - 6 Jul 2021

Garaulet Daniel L, Moro Albertomaria, Lai Eric C

Abstract excerpt

Virgin females of many species conduct distinctive behaviors, compared with post-mated and/or pregnant individuals. In Drosophila, this post-mating switch is initiated by seminal factors, implying that the default female state is virgin. However, we recently showed that loss of miR-iab-4/8-mediated repression of the transcription factor Homothorax (Hth) within the abdominal ventral nerve cord (VNC) causes virgins...

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Identifiers

PMID: 34233178
DOI: 10.1016/j.celrep.2021.109335
PMCID: PMC8344067

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