Article
Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Nadkarni Suchita, Smith Joanne, Sferruzzi-Perri Amanda N, Ledwozyw Agata, Kishore Madhav, Haas Robert, Mauro Claudio, Williams David J, Farsky Sandra H P, Marelli-Berg Federica M, Perretti Mauro
Abstract excerpt
Although neutrophils are known to be fundamental in controlling innate immune responses, their role in regulating adaptive immunity is just starting to be appreciated. We report that human neutrophils exposed to pregnancy hormones progesterone and estriol promote the establishment of maternal tolerance through the induction of a population of CD4+ T cells displaying a GARP+CD127loFOXP3+ phenotype following...
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