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Article

PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model

9 Nov 2016

Abstract excerpt

Inflammation is thought to play a critical role in the pathogenesis of placentation disorders such as recurrent miscarriages, growth restriction, and preeclampsia. Recently, neutrophil extracellular traps (NETs) have emerged as a potential mechanism for promoting inflammation in both infectious and noninfectious disorders. To investigate a pathogenic role for NETs in placentation disorders, we studied a model of...

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Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 28007693
DOI: 10.1095/biolreprod.116.140293

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