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Article

Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade.

Cancer immunology research - 1 Jan 2017

Nathanson Tavi, Ahuja Arun, Rubinsteyn Alexander, Aksoy Bulent Arman, Hellmann Matthew D, Miao Diana, Van Allen Eliezer, Merghoub Taha, Wolchok Jedd D, Snyder Alexandra, Hammerbacher Jeff

Abstract excerpt

Immune checkpoint inhibitors are promising treatments for patients with a variety of malignancies. Toward understanding the determinants of response to immune checkpoint inhibitors, it was previously demonstrated that the presence of somatic mutations is associated with benefit from checkpoint inhibition. A hypothesis was posited that neoantigen homology to pathogens may in part explain the link between somatic...

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Homology, Amino Acid

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Source

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Identifiers

PMID: 27956380
DOI: 10.1158/2326-6066.CIR-16-0019
PMCID: PMC5253347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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