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Article

CHD7 promotes proliferation of neural stem cells mediated by MIF

1 Dec 2016

Abstract excerpt

Macrophage migration inhibitory factor (MIF) plays an important role in supporting the proliferation and/or survival of murine neural stem/progenitor cells (NSPCs); however, the downstream effectors of this factor remain unknown. Here, we show that MIF increases the expression of Pax6 and Chd7 in NSPCs in vitro. During neural development, the chromatin remodeling factor Chd7 (chromatin helicase-DNA-binding...

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PMID: 27955690
DOI: 10.1186/s13041-016-0275-6

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