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Article

Genomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapies

17 Nov 2017

Abstract excerpt

Metastatic basal cell cancer (BCC) is an ultra-rare malignancy with no approved therapies beyond Hedgehog inhibitors. We characterized the genomics, tumor mutational burden (TMB), and anti-PD-1 therapy responses in patients with locally advanced or metastatic BCC. Overall, 2,039 diverse cancer samples that had undergone comprehensive genomic profiling (CGP) were reviewed. Eight patients with locally...

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PMID: 29399405
DOI: 10.1080/2162402x.2017.1404217

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