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Article

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen.

The Journal of biological chemistry - 30 Sept 2011

Baskaran Sulochanadevi, Chikwana Vimbai M, Contreras Christopher J, Davis Keri D, Wilson Wayne A, DePaoli-Roach Anna A, Roach Peter J, Hurley Thomas D

Abstract excerpt

Glycogen synthase is a rate-limiting enzyme in the biosynthesis of glycogen and has an essential role in glucose homeostasis. The three-dimensional structures of yeast glycogen synthase (Gsy2p) complexed with maltooctaose identified four conserved maltodextrin-binding sites distributed across the surface of the enzyme. Site-1 is positioned on the N-terminal domain, site-2 and site-3 are present on the C-terminal...

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Identifiers

PMID: 21835915
DOI: 10.1074/jbc.M111.264531
PMCID: PMC3190777

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Source receipt: pubmed, retrieved 7 Sept 2026.

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