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Article

Transcriptional response to mitochondrial protease IMMP2L knockdown in human primary astrocytes.

Biochemical and biophysical research communications - 22 Jan 2017

Gokoolparsadh Akira, Fang Zhiming, Braidy Nady, Lin Peijie, Pardy Christopher J, Eapen Valsamma, Clarke Raymond, Voineagu Irina

Abstract excerpt

IMMP2L encodes the inner membrane peptidase subunit 2, a mitochondrial protease involved in cleaving the space-sorting signals of mitochondrial membrane proteins. IMMP2L has been implicated in Tourette syndrome, but how its dysfunction contributes to the neurodevelopmental phenotype remains unclear. Here we show that IMMP2L transcription requires Topoisomerase I in human primary astrocytes, and characterize the...

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Identifiers

PMID: 27932244
DOI: 10.1016/j.bbrc.2016.12.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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