Article
Report From the First and Second Spanish Killer Immunoglobulin-Like Receptor Genotyping Workshops: External Quality Control for Natural Killer Alloreactive Donor Selection in Haploidentical Stem Cell Transplantation.
Transplantation proceedings - 1 Nov 2016
Planelles D, Vilches C, González-Escribano F, Muro M, González-Fernández R, Sánchez F, Gonzalo Ocejo J, Eiras A, Caro J L, Palou E, Campillo J A, de Juan M D, Montes O, Balas A, Marín L, Torío A, Fernández-Arquero M, González-Roiz C, López-Vázquez A, Cisneros E, Abad-Molina C, López R, Abad-Alastruey M L, Serra C, García-Alonso A M, Vicario J L
Abstract excerpt
An important factor affecting the success in the setting of related haploidentical hematopoietic stem cell transplantation (HSCT) is the graft-versus-leukemia effect mediated by natural killer (NK) cells when the donor displays NK alloreactivity versus the recipient. NK cell function is regulated by killer immunoglobulin-like receptors (KIR) and it has been described that donor KIR genotype influences...
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