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Killer Immunoglobulin-Like Receptor Allele Determination Using Next-Generation Sequencing Technology

19 May 2017

Abstract excerpt

The impact of Natural Killer (NK) cell alloreactivity on Hematopoietic Stem Cell Transplantation (HSCT) outcome is still debated due to the complexity of graft parameters, HLA class I environment, the nature of Killer Immunoglobulin-like Receptor (KIR)/KIR ligand genetic combinations studied and KIR+ NK cell repertoire size. KIR genes are known to be polymorphic in terms of gene content, copy number variation and...

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PMID: 28579987
DOI: 10.3389/fimmu.2017.00547

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