Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016

Lalancette-Hebert Melanie, Sharma Aarti, Lyashchenko Alexander K, Shneider Neil A

Abstract excerpt

The molecular and cellular basis of selective motor neuron (MN) vulnerability in amyotrophic lateral sclerosis (ALS) is not known. In genetically distinct mouse models of familial ALS expressing mutant superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS), we demonstrate selective degeneration of alpha MNs (α-MNs) and complete sparing of gamma MNs (γ-MNs), which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Motor Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscles

Share to Neurons, Afferent

Share to Spinal Cord

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 27930290
DOI: 10.1073/pnas.1605210113
PMCID: PMC5187676

Genes

SOD1
FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.PMID 27930290Read ↗

Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy.Semantic proximity Read ↗

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic miceSemantic proximity Read ↗

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis.Semantic proximity Read ↗

A Drosophila Model for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1Semantic proximity Read ↗

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death.Semantic proximity Read ↗

Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?Semantic proximity Read ↗

Locomotor deficits in ALS mice are paralleled by loss of V1-interneuron-connections onto fast motor neuronsSemantic proximity Read ↗

Motor pool selectivity of neuromuscular degeneration in type I spinal muscular atrophy is conserved between human and mouseSemantic proximity Read ↗

Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.Semantic proximity Read ↗

Circular continuum of alpha motoneuron typesSemantic proximity Read ↗

Absence of subcerebral projection neurons delays disease onset and extends survival in a mouse model of ALSSemantic proximity Read ↗

Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.