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Article

SIRT1‐SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide

7 Dec 2016

Abstract excerpt

Sirtuins are conserved NAD+‐dependent deacylases. SIRT1 is a nuclear and cytoplasmic sirtuin involved in the control of histones a transcription factors function. SIRT3 is a mitochondrial protein, which regulates mitochondrial function. Although, both SIRT1 and SIRT3 have been implicated in resistance to cellular stress, the link between these two sirtuins has not been studied so far. Here we aimed to unravel: i)...

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PMID: 27925196
DOI: 10.1002/jcp.25711

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