Article
A novel ABCC6 haplotype is associated with azathioprine drug response in myasthenia gravis.
Pharmacogenetics and genomics - 1 Feb 2017
Colleoni Lara, Galbardi Barbara, Barzago Claudia, Bonanno Silvia, Franzi Sara, Frangiamore Rita, Camera Giorgia, Foti Maria, Biancolini Donatella, Canioni Eleonora, Maggi Lorenzo, Antozzi Carlo, Mantegazza Renato, Bernasconi Pia, Kapetis Dimos
Abstract excerpt
OBJECTIVE: We investigated the association of single nucleotide polymorphisms (SNPs) in drug-metabolizing enzymes and transporters (DMETs) with the response to azathioprine (AZA) in patients affected by myasthenia gravis (MG) to determine possible genotype-phenotype correlations. PATIENTS AND METHODS: Genomic DNA from 180 AZA-treated MG patients was screened through the Affymetrix DMET platform, which...
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