Article
A Phase II Randomized Placebo-Controlled Trial of Oral N-acetylcysteine for Protection of Melanocytic Nevi against UV-Induced Oxidative Stress In Vivo.
Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2017
Cassidy Pamela B, Liu Tong, Florell Scott R, Honeggar Matthew, Leachman Sancy A, Boucher Kenneth M, Grossman Douglas
Abstract excerpt
Oxidative stress plays a role in UV-induced melanoma, which may arise from melanocytic nevi. We investigated whether oral administration of the antioxidant N-acetylcysteine (NAC) could protect nevi from oxidative stress in vivo in the setting of acute UV exposure. The minimal erythemal dose (MED) was determined for 100 patients at increased risk for melanoma. Patients were randomized to receive a single dose...
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