Article
Microdose-Induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice.
Molecular cancer therapeutics - 1 Feb 2017
Zimmermann Maike, Wang Si-Si, Zhang Hongyong, Lin Tzu-Yin, Malfatti Michael, Haack Kurt, Ognibene Ted, Yang Hongyuan, Airhart Susan, Turteltaub Kenneth W, Cimino George D, Tepper Clifford G, Drakaki Alexandra, Chamie Karim, de Vere White Ralph, Pan Chong-Xian, Henderson Paul T
Abstract excerpt
We report progress on predicting tumor response to platinum-based chemotherapy with a novel mass spectrometry approach. Fourteen bladder cancer patients were administered one diagnostic microdose each of [14C]carboplatin (1% of the therapeutic dose). Carboplatin-DNA adducts were quantified by accelerator mass spectrometry in blood and tumor samples collected within 24 hours, and compared with subsequent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.