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Article

Long Single-Molecule Reads Can Resolve the Complexity of the Influenza Virus Composed of Rare, Closely Related Mutant Variants.

Journal of computational biology : a journal of computational molecular cell biology - 1 Jun 2017

Artyomenko Alexander, Wu Nicholas C, Mangul Serghei, Eskin Eleazar, Sun Ren, Zelikovsky Alex

Abstract excerpt

As a result of a high rate of mutations and recombination events, an RNA-virus exists as a heterogeneous "swarm" of mutant variants. The long read length offered by single-molecule sequencing technologies allows each mutant variant to be sequenced in a single pass. However, high error rate limits the ability to reconstruct heterogeneous viral population composed of rare, related mutant variants. In this article,...

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Identifiers

PMID: 27901586
DOI: 10.1089/cmb.2016.0146
PMCID: PMC5467126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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